Recenzováno
Peroxisomal β-oxidation regulates histone acetylation and DNA methylation in Arabidopsis
Small-molecule metabolites from cell organelles or cytosol exert their influence on decision making processes in eukaryotic cells. However, the mechanisms underlying the regulation of cellular processes by these metabolites are not well understood. Among these small metabolites, acetyl-CoA, a most critical one, is produced in the cytosol and different cell organelles. In plants, acetyl-CoA produced from fatty acid β-oxidation in peroxisomes plays critical roles in various developmental stages. Here we found that defects in β-oxidation in peroxisomes affect both histone acetylation and DNA methylation in the nucleus. Our work provides evidence for retrograde signaling from peroxisomes to regulate nuclear epigenetic modifications in higher eukaryotes
Článek, 2019