Publication scientifique
Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy
Janika Viereck, Anne Bührke, Ariana Foinquinos, Shambhabi Chatterjee, Jan A Kleeberger, Ke Xiao, Heike Janssen-Peters, Sandor Batkai, Deepak Ramanujam, Theresia Kraft, Serghei Cebotari, Faikah Gueler, Andreas M Beyer, Jessica Schmitz, Jan H Bräsen, Jan D Schmitto, Mariann Gyöngyösi, Alexandra Löser, Marc N Hirt, Thomas Eschenhagen, Stefan Engelhardt, Christian Bär, Thomas Thum
Pathological cardiac remodelling and subsequent heart failure represents an unmet clinical need. Long non-coding RNAs (lncRNAs) are emerging as crucial molecular orchestrators of disease processes, including that of heart diseases. Here, we report on the powerful therapeutic potential of the conserved lncRNA H19 in the treatment of pathological cardiac hypertrophy
Article, 2020
European heart journal, 41, 20200921, 3462
2020