Front cover image for Behavioral Genetics

Behavioral Genetics

eBook, English, 2016
Worth Publishers, Incorporated, New York, 2016
1 online resource (847 pages)
9781464178931, 1464178933
1257666767
Intro
Title Page
Copyright
About the Authors
Preface
CHAPTER ONE: Overview
CHAPTER TWO: Historical Perspective
THE ERA OF DARWIN
Charles Darwin
Francis Galton
BOX 2.1 Francis Galton
PRE-MENDELIAN CONCEPTS OF HEREDITY AND VARIATION
Heredity
Variation
Summary
CHAPTER THREE: Mendel's Laws and Beyond
MENDEL'S LAWS
Mendel's First Law of Heredity
BOX 3.1 Gregor Mendel's Luck
BOX 3.2 How Do We Know That 1 in 50 People Are Carriers for PKU?
Mendel's Second Law of Heredity
BEYOND MENDEL'S LAWS
Complex Traits
Multiple-Gene Inheritance Quantitative Genetics
BOX 3.3 Liability-Threshold Model of Disorders
The X-Chromosome: An Extension to Mendel's Laws
Summary
CHAPTER FOUR: The Biological Basis of Heredity
DNA
BOX 4.1 The "Central Dogma" of Molecular Genetics
CHROMOSOMES
Summary
CHAPTER FIVE: Animal Models in Behavioral Genetics
QUANTITATIVE GENETIC EXPERIMENTS TO INVESTIGATE ANIMAL BEHAVIOR
Selection Studies
Inbred Strain Studies
ANIMAL STUDIES FOR IDENTIFYING GENES AND GENE FUNCTIONS
Creating Mutations
Quantitative Trait Loci
Synteny Homology
Summary CHAPTER SIX: Nature, Nurture, and Human Behavior
INVESTIGATING THE GENETICS OF HUMAN BEHAVIOR
Adoption Designs
BOX 6.1 The First Adoption Study of Schizophrenia
Twin Design
BOX 6.2 Issues in Adoption Studies
BOX 6.3 The Twin Method
Combination
Summary
CHAPTER SEVEN: Estimating Genetic and Environmental Influences
HERITABILITY
INTERPRETING HERITABILITY
BOX 7.1 Estimating Heritability Directly from DNA
ENVIRONMENTALITY
Shared Environment
Nonshared Environment
Estimating Shared and Nonshared Environmental Influences Identifying Specific Nonshared Environment
Identifying Specific Nonshared Environment That Predicts Behavioral Outcomes
MULTIVARIATE ANALYSIS
Summary
CHAPTER EIGHT: The Interplay between Genes and Environment
BEYOND HERITABILITY
GENOTYPE-ENVIRONMENT CORRELATION
The Nature of Nurture
Three Types of Genotype-Environment Correlation
Three Methods to Detect Genotype-Environment Correlation
Implications
GENOTYPE-ENVIRONMENT INTERACTION
Animal Models
Adoption Studies
Twin Studies
DNA
Summary
CHAPTER NINE: Identifying Genes
MUTATIONS Expanded Triplet Repeats
DETECTING POLYMORPHISMS
BOX 9.1 DNA Markers
HUMAN BEHAVIOR
Linkage: Single-Gene Disorders
Linkage: Complex Disorders
Association: Candidate Genes
BOX 9.2 Affected Sib-Pair Linkage Design
Association: Genomewide
BOX 9.3 SNP Microarrays
Summary
CHAPTER TEN: Pathways between Genes and Behavior
GENE EXPRESSION AND THE ROLE OF EPIGENETICS
BOX 10.1 Levels of Analysis
THE TRANSCRIPTOME: GENE EXPRESSION THROUGHOUT THE GENOME
Gene Expression Profiles: RNA Microarrays and Sequence-Based Approaches
Gene Expression and Genetics
Gene Expression as a Biological Basis for Environmental Influence