The oncogene and tumour suppressor gene factsbook
The Second Edition of The Oncogene and Tumour Suppressor Gene FactsBook has been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes including JUN, MYC, and RAS, as well as DNA tumour viruses, tumour suppressor genes, including p53, retinoblastoma, BRCA1, BRCA2, VHL, F2FL, and essential material on angiogenesis and metastasis, apoptosis, cell cycle control, and gene therapy. Key Features * Includes much new data on this fast-moving field, including newly discovered oncogenes * Summarizes the clinical association and molecular properties of all known oncogenes and tumor suppression genes * Contains more than 2000 terms for reference and further research * Revised to included signaling pathways, apoptosis, and metastasis
1 online resource (xiv, 549 pages) : illustrations
9780123445483, 9780080538006, 0123445485, 0080538002
162572729
The Introductory Chapters:
Introduction: Identification of Oncogenes
Oncogene Activation in Humans
Proliferation Control Pathways: Oncoprotein Function
Growth Factor-Related Proteins
SRC. RAS and RAF
Nuclear Oncoproteins
ETS. FOS and JUN. MYB. MYC. REL. ERBA
Tumour Suppressor Genes: RB1. P53
Other Major Tumour Suppressor Genes
APC. BRCA1. NF1. VHL. WT1
Cell Cycle Control: Cyclin-Dependent Kinase Inhibitors (CDKIs)
Apoptosis: Tumour Suppressor Genes and Apoptosis
DNA Repair
Angiogenesis and Metastasis: Angiogenesis
Angiogenic Promoters
Angiogenic Inhibitors
Metastasis: Correlations with Gene Expression
Cadherins
The Immunoglobulin Superfamily (IgSF), Neural Cell-Adhesion Molecule (NCAM)
Integrins
CD44
Matrix Metalloproteinases (MMPS)
Tissue Inhibitors of Metalloproteinases (TIMPs)
Cysteine and Aspartic Proteinases and Heparanase
NME1 and NME2
The Multi-step Nature of Cancer: Cervical Carcinoma
Colorectal Carcinoma
Breast Carcinoma
Prostate Carcinoma
Renal Cell Carcinoma
Lung Carcinoma
Lymphomas
Chronic Myeloid Leukemia
Gene Therapy for Cancer: Nucleotide Sequence-Targeted Strategies
Tumour Suppressor Gene Therapy
Cytokine Gene Therapy and Tumour Vaccination
Virally Directed Enzyme Prodrug Therapy (VDEPT)
Antibody-directed Therapy
Tables:
Oncogenes Transduced by Retroviruses
Oncogenes Activated by Retroviral Insertion
Oncogenes at Chromosomal Translocations
Tumour Suppressor Genes Detected in Human Tumours
Functions of Oncoproteins
Chromosome Locations of Human Proto-Oncogenes and Tumour Suppressor Genes
The Oncogenes:
ABL. AKT1 and AKT2. BCL2. BCL3. BCR. CBL. CDK4. CRK. CSFIR/FMS. D Cyclins. DBL. EGFR/ErbB. ELK1. EPH. ERG. ETS1 and ETS2. FGR. FLII. FOS. FOSB. FPS/FES. FRA1 and FRA2. FYN. HCK. HER2/ErbB-2/Neu. HER3/ErbB-3. HER4/ErbB-4. HSTF1/HST2. INT2. JUN. JUNB. JUND. KIT. LCK. LYN. MAS. MAX. MET. Mil. MOS. MYB. MYC. PDGF/Sis. PIM1. RAF. RAS. REL. RET. ROS1. SEA. SKI. SRC. TAL1. THRA/ErbA-1 and THRA2/ErbA-2. TIAM1. TRK. VAV. WNT1. WNT2 and WNT3. YES1
Tumour Suppressor Genes:
APC and MCC. BRCA1 and BRCA2. DCC. DPC4. E2F1. E-cadherin/CDH1. MSH2. MSH3. MSH6/GTBP and MLHL. NF1 and NF2. P53, PTC
The Retinoblastoma Gene (RB1). TGFBR1 and TGFBR2. VHL; WT1
Cyclin-dependent Kinase Inhibitors:
INK4A/MTS1/MTS2/CDK41/CDKN2. INK4B/MTS2
INK4C and INK4D. KIP1. KIP2. WAF1
DNA Tumour Viruses:
Human Papillomaviruses
Epstein-Barr Virus
Subject Index. Sect. 1. The introductory chapters
Genetic events in cancer delelopment
Proliferation control pathways
Tumour suppressor genes
Cell cycle control
Apoptosis
DNA repair
Angiogenesis and metastasis
The multistep nature of cancer
Gene therapy for cancer
Sect. 2. Tables
Oncogenes transduced by retroviruses
Oncogenes activated by retroviral insertion
Oncogenes at chromosomal translocations
Tumour suppressor genes detected in human tumours
Functions of oncoproteins
Chromosome locations of human proto-oncogenes and tumour
suppressor genes
Sect. 3. The oncogenes
Sect. 4. Tumour suppressor genes
Sect. 5. Cyclin-dependent kinase inhibitors
Sect. 6. DNA tumour viruses