Peer-reviewed
Probing the photostability of avobenzone with N-acetylcysteine using UV spectroscopy, computational studies and integration into aloe vera gel
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• N-acetylcysteine acts as a photostabilizer of avobenzone under natural sunlight. • N-acetylcysteine can deactivate the excited state of the keto-avobenzone. • N-acetylcysteine promotes keto-enol tautomerization by lowering the activation energy barrier. • Avobenzone, N-acetylcysteine, and glutathione can be integrated into eco-friendly aloevera gel. • The newly formulated gel may provide holistic protection to the skin against UVA radiation/sunlight.
N-acetylcysteine is a biomolecule with broader applications in dermatology and cosmetics. Its radical scavenging activity in the cell is prompting the evaluation of its photostabilization activity on the avobenzone. N-acetylcysteine retards the photodegradation of avobenzone in ethanol and promotes the competitive recovery of enol-form in acetonitrile as evaluated using UV-spectroscopy under natural sunlight. Optoelectronics and activation energy calculations have been undertaken to understand the molecular basis of photostabilization/recovery of enol-forms of avobenzone by the N-acetylcysteine. The result indicates that N-acetylcysteine may quench the excited state of keto-avobenzone formed by the photoketonization process and also promotes keto-to-enol tautomerization of avobenzone by lowering the activation energy barrier by 41 kcal/mole. These experimental and computational studies confirm N-acetylcysteine as a photostabilizer of avobenzone. Given the N-acetylcysteine as a wound healing agent and glutathione as a skin whitener, the report has integrated avobenzone, N-acetylcysteine, and glutathione into the eco-friendly aloe vera gel to provide holistic protection against UV-A radiation/sunlight. The new method has been developed to assess the stability of avobenzone in the integrated gel and further monitor the thiol content of N-acetylcysteine/glutathione in the gel using Ellman's reagent. The newly integrated aloe vera gel exhibits a stable UV-A filtering activity at room temperature and upon exposure to sunlight. The report's results may find applications in developing next-generation cosmetic aesthetic medicines
• N-acetylcysteine acts as a photostabilizer of avobenzone under natural sunlight. • N-acetylcysteine can deactivate the excited state of the keto-avobenzone. • N-acetylcysteine promotes keto-enol tautomerization by lowering the activation energy barrier. • Avobenzone, N-acetylcysteine, and glutathione can be integrated into eco-friendly aloevera gel. • The newly formulated gel may provide holistic protection to the skin against UVA radiation/sunlight.
N-acetylcysteine is a biomolecule with broader applications in dermatology and cosmetics. Its radical scavenging activity in the cell is prompting the evaluation of its photostabilization activity on the avobenzone. N-acetylcysteine retards the photodegradation of avobenzone in ethanol and promotes the competitive recovery of enol-form in acetonitrile as evaluated using UV-spectroscopy under natural sunlight. Optoelectronics and activation energy calculations have been undertaken to understand the molecular basis of photostabilization/recovery of enol-forms of avobenzone by the N-acetylcysteine. The result indicates that N-acetylcysteine may quench the excited state of keto-avobenzone formed by the photoketonization process and also promotes keto-to-enol tautomerization of avobenzone by lowering the activation energy barrier by 41 kcal/mole. These experimental and computational studies confirm N-acetylcysteine as a photostabilizer of avobenzone. Given the N-acetylcysteine as a wound healing agent and glutathione as a skin whitener, the report has integrated avobenzone, N-acetylcysteine, and glutathione into the eco-friendly aloe vera gel to provide holistic protection against UV-A radiation/sunlight. The new method has been developed to assess the stability of avobenzone in the integrated gel and further monitor the thiol content of N-acetylcysteine/glutathione in the gel using Ellman's reagent. The newly integrated aloe vera gel exhibits a stable UV-A filtering activity at room temperature and upon exposure to sunlight. The report's results may find applications in developing next-generation cosmetic aesthetic medicines
Article, 2024