Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
Wark, Peter A.B. (Creator), Johnston, Sebastian L. (Creator), Bucchieri, Fabio (Creator), Powell, Robert (Creator), Puddicombe, Sarah (Creator), Laza-Stanca, Vasile (Creator), Holgate, Stephen T. (Creator), Davies, Donna E. (Creator)
Rhinoviruses are the major trigger of acute asthma exacerbations and asthmatic subjects are more susceptible to these infections. To investigate the underlying mechanisms of this increased susceptibility, we examined virus replication and innate responses to rhinovirus (RV)-16 infection of primary bronchial epithelial cells from asthmatic and healthy control subjects
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