Front cover image for Isolation and characterization of a human dna binding protein which contains an antp homeobox sequence

Isolation and characterization of a human dna binding protein which contains an antp homeobox sequence

Protein factors have been identified that bind DNA and regulate mammalian transcription. Several of these factors bind at, or around, the TATA box. To isolate additional TATA-recognizing factors, we screened a human B-cell $\lambda$gt11 expression library with a radiolabeled TATAA repeated probe. One recombinant clone bound specifically to the TATAA repeated sequence. The binding clone contained a class I homeobox that was identical in 59/60 residues to the Drosophila Antp homeobox. The homeobox cDNA

Thesis, Dissertation, English, 1990