Advanced practical organic chemistry
J. Leonard (Author), B. Lygo (Author), Garry Procter (Author)
General introductionSafetySafety is your primary responsibilitySafe working practiceSafety risk assessmentsCommon hazardsAccident and emergency proceduresBibliographyKeeping records of laboratory workIntroductionThe laboratory notebookKeeping records of dataSome tips on report and thesis preparationReferencesEquipping the laboratory and the benchIntroductionSetting up the laboratoryGeneral laboratory equipmentThe individual benchEquipment for parallel experimentsEquipment for controlled experimentationPurification and drying of solventsIntroductionPurification of solventsDrying agentsDrying of solventsReferencesReagents: Preparation, purification, and handlingIntroductionClassification of reagents for handlingTechniques for obtaining pure and dry reagentsTechniques for handling and measuring reagentsPreparation and titration of simple organometallic reagents and lithium amide basesPreparation of diazomethaneReferencesGasesIntroductionUse of gas cylindersHandling gasesMeasurement of gasesInert gasesReagent gasesReferencesVacuum pumpsIntroductionHouse vacuum systems (low vacuum)Medium vacuum pumpsHigh vacuum pumpsPressure measurement and regulationCarrying out the reactionIntroductionReactions with air-sensitive reagentsReaction monitoringReactions at other than room temperatureDriving equilibriaAgitationUse of controlled reactor systemsReferencesWorking up the reactionIntroductionQuenching the reactionIsolation of the crude productData that need to be collected on the crude product prior to purificationPurificationIntroductionCrystallizationDistillationSublimationFlash chromatographyDry-column flash chromatographyPreparative TLCMedium pressure and prepacked chromatography systemsPreparative HPLCReferencesSmall-scale reactionsIntroductionReactions at or below room temperatureReactions above room temperatureReactions in NMR tubesPurification of
eBook, English, 2013
CRC Press, Taylor & Francis Group, Boca Raton, 2013