Insulin signalling in endothelial cells
However, this did not affect endothelial permeability, suggesting that these proteins are important for maintaining tight junction integrity. LM07 and Epsin2 depletion each resulted in an increase in angiogenic loop formation, but did not detectably affect cell migration. Insulin stimulation of Epsin2 might increase lamellipodium formation, although further studies are required to establish the mechanisms involved. In conclusion, this thesis describes a 14-3-3-based proteomic screen that identified novel regulators of endothelial function. These proteins could contribute to the antiinflammatory roles of insulin
Thesis, Dissertation, English, 2014